Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization.

ABSTRACT:

Context

Familial combined hypolipidemia causes a global reduction of plasma lipoproteins. Its clinical correlates and metabolic implications have not been well defined.

Objective

The objective of the study was to investigate the genetic, clinical, and metabolic characteristics of a cohort of subjects with familial combined hypolipidemia.

Design

The design of the study included candidate gene screening and the comparison of the clinical and metabolic characteristics between carrier and noncarrier individuals.

Setting

The study was conducted in a general community.

Subjects

Participants in the study included individuals belonging to nine families with familial combined hypolipidemia identified in a small town (Campodimele) as well as from other 352 subject

SUBMITTER: Minicocci I 

PROVIDER: S-EPMC5393441 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature