The effect of leptin replacement on parathyroid hormone, RANKL-osteoprotegerin axis, and Wnt inhibitors in young women with hypothalamic amenorrhea.

ABSTRACT:

Context

Recombinant leptin (metreleptin) treatment restores bone mineral density in women with hypothalamic amenorrhea (HA), a condition characterized by hypoleptinemia, which has adverse impact on bone health.

Objective

The objective of the study was to investigate how metreleptin exerts its positive effect on bone metabolism in humans.

Design

This was a randomized, double-blinded, placebo-controlled study.

Setting

The study was conducted at Beth Israel Deaconess Medical Center (Boston, Massachusetts).

Patients and interventions

Women (n = 18) with HA and hypoleptinemia for at least 6 months were randomized to receive either metreleptin or placebo for 36 weeks. Serum samples were obtained at baseline and 12, 24, and 36 weeks of treatment.

Main outcom

SUBMITTER: Foo JP 

PROVIDER: S-EPMC5393498 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature