Absence of antibodies against KIR4.1 in multiple sclerosis: A three-technique approach and systematic review.

ABSTRACT:

Introduction

Antibodies targeting the inward-rectifying potassium channel KIR4.1 have been associated with multiple sclerosis (MS) but studies using diverse techniques have failed to replicate this association. The detection of these antibodies is challenging; KIR4.1 glycosylation patterns and the use of diverse technical approaches may account for the disparity of results. We aimed to replicate the association using three different approaches to overcome the technical limitations of a single technique. We also performed a systematic review to examine the association of anti-KIR4.1 antibodies with MS.

Methods

Serum samples from patients with MS (n = 108) and controls (n = 77) were tested for the presence of anti-KIR4.1 antibodies using three methods: 1) by ELISA with the low

SUBMITTER: Navas-Madronal M 

PROVIDER: S-EPMC5393569 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature