Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells.

ABSTRACT: The testis has been identified as the organ in which a large number of tissue-enriched genes are present. However, a large portion of transcripts related to each stage or cell type in the testis still remains unknown. In this study, databases combined with confirmatory measurements were used to investigate testis-enriched genes, localization in the testis, developmental regulation, gene expression profiles of testicular disease, and signaling pathways. Our comparative analysis of GEO DataSets showed that 24 genes are predominantly expressed in testis. Cellular locations of 15 testis-enriched proteins in human testis have been identified and most of them were located in spermatocytes and round spermatids. Real-time PCR revealed that expressions of these 15 genes are significantly increased

SUBMITTER: Ahn J 

PROVIDER: S-EPMC5393594 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature