The nanoparticle protein corona formed in human blood or human blood fractions.

ABSTRACT: The protein corona formed around nanoparticles in protein-rich fluids plays an important role for nanoparticle biocompatibility, as found in several studies during the last decade. Biological fluids have complex compositions and the molecular components interact and function together in intricate networks. Therefore, the process to isolate blood or the preparation of blood derivatives may lead to differences in the composition of the identified protein corona around nanoparticles. Here, we show distinct differences in the protein corona formed in whole blood, whole blood with EDTA, plasma, or serum. Furthermore, the ratio between particle surface area to protein concentration influences the detected corona. We also show that the nanoparticle size per se influences the formed protein corona

SUBMITTER: Lundqvist M 

PROVIDER: S-EPMC5393619 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature