Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection.

ABSTRACT:

Rationale

Understanding mechanisms of resistance to M. tuberculosis (M.tb) infection in humans could identify novel therapeutic strategies as it has for other infectious diseases, such as HIV.

Objectives

To compare the early transcriptional response of M.tb-infected monocytes between Ugandan household contacts of tuberculosis patients who demonstrate clinical resistance to M.tb infection (cases) and matched controls with latent tuberculosis infection.

Methods

Cases (n = 10) and controls (n = 18) were selected from a long-term household contact study in which cases did not convert their tuberculin skin test (TST) or develop tuberculosis over two years of follow up. We obtained genome-wide transcriptional profiles of M.tb-infected peripheral blood monocytes and used Gen

SUBMITTER: Seshadri C 

PROVIDER: S-EPMC5393882 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature