Downregulation of neuronal vasoactive intestinal polypeptide in Parkinson's disease and chronic constipation.

ABSTRACT:

Background

Chronic constipation (CC) is a common and severe gastrointestinal complaint in Parkinson's disease (PD), but its pathogenesis remains poorly understood. This study evaluated functionally distinct submucosal neurons in relation to colonic motility and anorectal function in PD patients with constipation (PD/CC) vs both CC and controls.

Methods

Twenty-nine PD/CC and 10 Rome III-defined CC patients were enrolled. Twenty asymptomatic age-sex matched subjects served as controls. Colonic transit time measurement and conventional anorectal manometry were evaluated in PD/CC and CC patients. Colonoscopy was performed in all three groups. Colonic submucosal whole mounts from PD/CC, CC, and controls were processed for immunohistochemistry with antibodies for vasoactive intest

SUBMITTER: Giancola F 

PROVIDER: S-EPMC5393951 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature