Association of IL4, IL13, and IL4R polymorphisms with gastrointestinal cancer risk: A meta-analysis.

ABSTRACT:

Background

Previous studies have suggested that IL4, IL13, and IL4R are associated with serum IgE levels and allergies, and common variants of these genes may alter cancer risk. To clarify these associations, we conducted a meta-analysis to investigate the associations of IL4, IL13, and IL4R polymorphisms with gastrointestinal cancer risk.

Methods

We used 27 eligible case-control studies describing the associations of six polymorphisms of IL4, IL13, and IL4R with gastrointestinal cancer risk to calculate summary odds ratios (ORs) and 95% confidence intervals (CIs) using five different genetic models. The Q-statistic and I² statistic were calculated to examine heterogeneity.

Results

The IL4 rs2070874 T allele seems to be associated with an increased risk of

SUBMITTER: Cho YA 

PROVIDER: S-EPMC5394226 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature