Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial.

ABSTRACT:

Purpose

Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial. We aimed to confirm the proposed superiority of oral nifedipine 60 mg per day over placebo for treatment of chronic chilblains in primary care.

Methods

We performed a randomized, placebo-controlled, double-blind, crossover trial, closely following the design of the older trial. A total of 32 patients with chronic chilblains were randomly assigned to nifedipine (30 mg controlled release twice a day) or placebo. The primary outcome was patient-reported complaints; the secondary outcome was patient-reported disability. Both were assessed from daily ratings on 100-mm visual analogue scales recorded in a diar

SUBMITTER: Souwer IH 

PROVIDER: S-EPMC5394377 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature