Cyclic GMP-dependent protein kinase-I localized in nociceptors modulates nociceptive cortical neuronal activity and pain hypersensitivity.
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ABSTRACT: Abstract
Chronic pain represents a frequent and poorly understood public health issue. Numerous studies have documented the key
SUBMITTER: Gangadharan V
PROVIDER: S-EPMC5394618 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Cyclic GMP-dependent protein kinase-I localized in nociceptors modulates nociceptive cortical neuronal activity and pain hypersensitivity.
Gangadharan Vijayan V Wang Xu X Luo Ceng C
Molecular pain 20170101
<h4>Abstract</h4>Chronic pain represents a frequent and poorly understood public health issue. Numerous studies have documented the key significance of plastic changes along the somatosensory pain pathways in chronic pain states. Our recent study demonstrated that the cGMP-dependent protein kinase I (PKG-I) specifically localized in nociceptors constitutes a key mediator of hyperexcitability of primary sensory neurons and spinal synaptic plasticity after inflammation. However, whether PKG-I in n ...[more]
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