Phase I clinical trial of combination imatinib and ipilimumab in patients with advanced malignancies.

ABSTRACT:

Background

Imatinib mesylate can induce rapid tumor regression, increase tumor antigen presentation, and inhibit tumor immunosuppressive mechanisms. CTLA-4 blockade and imatinib synergize in mouse models to reduce tumor volume via intratumoral accumulation of CD8+ T cells. We hypothesized that imatinib combined with ipilimumab would be tolerable and may synergize in patients with advanced cancer.

Methods

Primary objective of the dose-escalation study (3 + 3 design) was to establish the maximum tolerated dose (MTD) and recommended phase II dose. Secondary objectives included evaluation of antitumor activity of the combination based on KIT mutation status and the capacity of tumor-associated immune biomarkers to predict response.

Results

The primary objective to establi

SUBMITTER: Reilley MJ 

PROVIDER: S-EPMC5394629 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature