Group V Secreted Phospholipase A₂ Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils.

ABSTRACT: Secreted phospholipases A₂ (sPLA₂s) are extracellular enzymes that catalyze the release of free fatty acids and lysophospholipids from membrane phospholipids and also bind to different receptors (e.g., PLA₂R1 or integrins). To date, 12 mammalian sPLA₂s have been identified, which play a critical role in pathophysiological processes including inflammation and cancer. sPLA₂s activate immune cells such as human neutrophils (PMNs) by enzymatic activity- or receptor-mediated mechanisms. In addition, human PMNs synthesize and store human group V (hGV) and human group X (hGX) sPLA₂s in their granules, but only the former is released upon cellular activation. We investigated the effects of sPLA₂s on the release of proangi

SUBMITTER: Loffredo S 

PROVIDER: S-EPMC5394767 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature