Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control.

ABSTRACT:

Rationale

Maintaining optimal symptom control remains the primary objective of asthma treatment. Better understanding of the biologic underpinnings of asthma control may lead to the development of improved clinical and pharmaceutical approaches.

Objectives

To identify molecular pathways and interrelated genes whose differential expression was associated with asthma control.

Methods

We performed gene set enrichment analyses of asthma control in 1,170 adults with asthma, each with gene expression data derived from either whole blood (WB) or unstimulated CD4⁺ T lymphocytes (CD4), and a self-reported asthma control score representing either the preceding 6 months (chronic) or 7 days (acute). Our study comprised a discovery WB cohort (n = 245, chronic) and three

SUBMITTER: Croteau-Chonka DC 

PROVIDER: S-EPMC5394783 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature