The Effect of Aerosol Saline on Laboratory-Induced Dyspnea.

ABSTRACT:

Purpose

In the 'placebo arm' of a recent study, we found that aerosol saline (sham treatment) produced substantial relief of laboratory-induced dyspnea (Breathing discomfort-BD) in nearly half the subjects. The sham intervention included a physiological change, and instructions to subjects could have produced expectation of dyspnea relief. In the present study, we attempted to discover whether the response to sham aerosol was driven by behavioral or physiological aspects of the intervention.

Methods

Dyspnea (air hunger) was evoked by constraining tidal volume during graded hypercapnia. We measured [Formula: see text] versus BD relationship before and after aerosol saline. To minimize subjects' expectations of dyspnea relief, participants were clearly instructed that we would

SUBMITTER: O'Donnell CR 

PROVIDER: S-EPMC5394930 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature