Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency.

ABSTRACT: Iron plays the central role in oxygen transport by erythrocytes as a constituent of heme and hemoglobin. The importance of iron and heme is also to be found in their regulatory roles during erythroblast maturation. The transcription factor Bach1 may be involved in their regulatory roles since it is deactivated by direct binding of heme. To address whether Bach1 is involved in the responses of erythroblasts to iron status, low iron conditions that induced severe iron deficiency in mice were established. Under iron deficiency, extensive gene expression changes and mitophagy disorder were induced during maturation of erythroblasts. Bach1^-/- mice showed more severe iron deficiency anemia in the developmental phase of mice and a retarded recovery once iron was replenished when

SUBMITTER: Kobayashi M 

PROVIDER: S-EPMC5394953 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature