Intracranial atherosclerosis and dementia: The Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Objective

To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia.

Methods

From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the population-based Atherosclerosis Risk in Communities Study by a sampling strategy that allowed weighting back to the cohort. We defined ICAD by plaque features (presence, territory, stenosis, number). Trained clinicians used an algorithm incorporating information from interviews and neuropsychological and neurologic examinations to adjudicate for MCI and dementia. We determined the relative prevalence ratio (RPR) of MCI or dementia after adjusting for risk factors at midlife using multinomial logistic regression.

Results

A total of 601 (34.

SUBMITTER: Dearborn JL 

PROVIDER: S-EPMC5395073 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature