Physical activity and hippocampal volume in middle-aged patients with type 1 diabetes.

ABSTRACT:

Objective

To examine the cross-sectional association between physical activity (PA) and hippocampal volume in middle-aged adults with childhood-onset type 1 diabetes (T1D), and whether hyperglycemia and insulin sensitivity contribute to this relationship.

Methods

We analyzed neuroimaging and self-reported PA data from 79 adults with T1D from the Pittsburgh Epidemiology of Diabetes Complications Study (mean age 50 years, mean duration 41 years) and 122 similarly aged adults without T1D (mean age 48 years). Linear regression models, controlling for intracranial volume, sex, education, and age, tested associations between PA and gray matter volumes of hippocampi and total brain in the 2 groups. For the T1D group, models further controlled for hyperglycemia and glucose disposal

SUBMITTER: Nunley KA 

PROVIDER: S-EPMC5395074 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature