Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals.

ABSTRACT:

Importance

White persons have a higher risk of atrial fibrillation (AF) compared with black individuals despite a lower prevalence of risk factors. This difference may be due, at least in part, to genetic factors.

Objectives

To determine whether 9 single-nucleotide polymorphisms (SNPs) associated with AF account for this paradoxical differential racial risk for AF and to use admixture mapping to search genome-wide for loci that may account for this phenomenon.

Design, setting, and participants

Genome-wide admixture analysis and candidate SNP study involving 3 population-based cohort studies that were initiated between 1987 and 1997, including the Cardiovascular Health Study (CHS) (n = 4173), the Atherosclerosis Risk in Communities (ARIC) (n = 12 341) study, and the He

SUBMITTER: Roberts JD 

PROVIDER: S-EPMC5395094 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature