CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27^kip1 signaling.

ABSTRACT: Targeting leukemia initiating cells is considered to be an effective way to cure leukemia, for which it is critical to identify novel therapeutic targets. Herein, we demonstrate that CD244, which was initially reported as a key regulator for natural killer cells, is highly expressed on both mouse and human leukemia initiating cells. Upon CD244 knockdown, human leukemia cell lines and primary leukemia cells have markedly impaired proliferation abilities both in vitro and in vivo Interestingly, the repopulation ability of both mouse and human hematopoietic stem cells is not impaired upon CD244 knockdown. Using an MLL-AF9-induced murine acute myeloid leukemia model, we show that leukemogenesis is dramatically delayed upon CD244 deletion, together with remarkably reduced Mac1

SUBMITTER: Zhang F 

PROVIDER: S-EPMC5395111 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature