Lenalidomide combined with intensive chemotherapy in acute myeloid leukemia and higher-risk myelodysplastic syndrome with 5q deletion. Results of a phase II study by the Groupe Francophone Des Myelodysplasies.

ABSTRACT: Patients with acute myeloblastic leukemia or higher risk myelodysplastic syndromes with 5q deletion (generally within a complex karyotype) respond poorly to intensive chemotherapy and have very poor survival. In this population, we evaluated escalating doses of lenalidomide combined with intensive chemotherapy in a phase II study. Treatment consisted of daunorubicin (45 mg/m²/day, days 1-3 in cohort 1, escalated to 60 mg/m²/day, days 1-3 in cohorts 2 and 3) combined with cytosine arabinoside (200 mg/m²/day, days 1-7) and lenalidomide (10 mg/day, days 1-21 in cohorts 1 and 2, escalated to 25 mg/day, days 1-21 in cohort 3). Eighty-two patients with 5q deletion were enrolled, including 62 with acute myeloblastic leukemia, 62/79 (78%) of whom had a complex kary

SUBMITTER: Ades L 

PROVIDER: S-EPMC5395113 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature