Effect of genomic distance on coexpression of coregulated genes in E. coli.

ABSTRACT: In prokaryotes, genomic distance is a feature that in addition to coregulation affects coexpression. Several observations, such as genomic clustering of highly coexpressed small regulons, support the idea that coexpression behavior of coregulated genes is affected by the distance between the coregulated genes. However, the specific contribution of distance in addition to coregulation in determining the degree of coexpression has not yet been studied systematically. In this work, we exploit the rich information in RegulonDB to study how the genomic distance between coregulated genes affects their degree of coexpression, measured by pairwise similarity of expression profiles obtained under a large number of conditions. We observed that, in general, coregulated genes display higher degrees of

SUBMITTER: Pannier L 

PROVIDER: S-EPMC5395161 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature