A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis.

ABSTRACT:

Introduction

Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. Experimental and small clinical trials have demonstrated that angiotensin II blockers (ARB) may be anti-fibrotic in the liver. The aim of this randomised controlled trial was to assess whether treatment with Losartan for 96 weeks slowed, halted or reversed the progression of fibrosis in patients with non-alcoholic steatohepatitis (NASH).

Methods

Double-blind randomised-controlled trial of Losartan 50 mg once a day versus placebo for 96 weeks in patients with histological evidence of NASH. The primary outcome for the study was change in histological fibrosis stage from pre-treatment to end-of-treatment.

Results

The study planned to recruit 214 patients. However, recruitment was

SUBMITTER: McPherson S 

PROVIDER: S-EPMC5395178 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature