Association of systemic inflammation, adiposity, and metabolic dysregulation with asthma burden among Hispanic adults.

ABSTRACT:

Rationale

Obesity-related asthma is associated with higher disease burden than normal-weight asthma among Hispanics. Adiposity, metabolic dysregulation, and inflammation are all implicated in pathogenesis of obesity-related asthma, but their independent contributions are poorly understood.

Objective

To examine the independent contributions of body fat distribution, metabolic abnormalities and inflammation on asthma symptoms and pulmonary function among Hispanics.

Methods

Participants of the Hispanic Community Health Study/Study of Latinos with doctor-diagnosed asthma who completed an asthma symptom questionnaire and performed a valid spirometry were included in the analysis (n = 1126). Multivariate analysis was used to examine the independent association of general ad

SUBMITTER: Rastogi D 

PROVIDER: S-EPMC5395248 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature