Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics.

ABSTRACT:

Background

Narcolepsy, a disorder of rapid eye movement (REM) sleep, is characterized by excessive daytime sleepiness and cataplexy, a loss of muscle tone triggered by emotional stimulation. Current narcolepsy pharmacotherapeutics include controlled substances with abuse potential or drugs with undesirable side effects. As partial agonists at trace amine-associated receptor 1 (TAAR1) promote wakefulness in mice and rats, we evaluated whether TAAR1 agonism had beneficial effects in two mouse models of narcolepsy.

Methods

In the first experiment, male homozygous B6-Taar1^{tm1(NLSLacZ)Blt} (Taar1 knockout) and wild-type mice were surgically implanted to record electroencephalogram, electromyogram, locomotor activity, and body temperature, and the efficacy of the TAAR1 a

SUBMITTER: Black SW 

PROVIDER: S-EPMC5395352 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature