Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling.

ABSTRACT: Several neuropsychiatric and neurodegenerative disorders share stress as a risk factor and are more prevalent in women than in men. Corticotropin-releasing factor (CRF) orchestrates the stress response, and excessive CRF is thought to contribute to the pathophysiology of these diseases. We previously found that the CRF₁ receptor (CRF₁) is sex biased whereby coupling to its GTP-binding protein, Gs, is greater in females, whereas β-arrestin-2 coupling is greater in males. This study used a phosphoproteomic approach in CRF-overexpressing (CRF-OE) mice to test the proof of principle that when CRF is in excess, sex-biased CRF₁ coupling translates into divergent cell signaling that is expressed as different brain phosphoprotein profiles. Cortical phosphopeptides

SUBMITTER: Bangasser DA 

PROVIDER: S-EPMC5395355 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature