Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction.

ABSTRACT: The preparation of unsaturated secondary lactams via the palladium-catalyzed cyclization of O-phenyl hydroxamates onto a pendent alkene is reported. This method provides rapid access to a broad range of lactams that are widely useful building blocks in alkaloid synthesis. Mechanistic studies support an aza-Heck-type pathway.

SUBMITTER: Shuler SA 

PROVIDER: S-EPMC5395365 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature