Epigenetic landscapes reveal transcription factors that regulate CD8⁺ T cell differentiation.

ABSTRACT: Dynamic changes in the expression of transcription factors (TFs) can influence the specification of distinct CD8⁺ T cell fates, but the observation of equivalent expression of TFs among differentially fated precursor cells suggests additional underlying mechanisms. Here we profiled the genome-wide histone modifications, open chromatin and gene expression of naive, terminal-effector, memory-precursor and memory CD8⁺ T cell populations induced during the in vivo response to bacterial infection. Integration of these data suggested that the expression and binding of TFs contributed to the establishment of subset-specific enhancers during differentiation. We developed a new bioinformatics method using the PageRank algorithm to reveal key TFs that influence the generation o

SUBMITTER: Yu B 

PROVIDER: S-EPMC5395420 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature