Deciphering the Regulatory Network between the SREBP Pathway and Protein Secretion in Neurospora crassa.

ABSTRACT: Sterol regulatory element binding proteins (SREBPs) are conserved from yeast to mammalian cells and function in the regulation of sterol homeostasis. In fungi, the SREBP pathway has been implicated in the adaptation to hypoxia and in virulence. In Neurospora crassa and Trichoderma reesei, the SREBP pathway also negatively regulates protein secretion under lignocellulolytic conditions. Here we utilized global transcriptional profiling combined with genetic and physiological analyses to address the regulatory link between the SREBP pathway and protein secretion in N. crassa Our results demonstrated that the function of the SREBP pathway in ergosterol biosynthesis and adaptation to hypoxia was conserved in N. crassa Under lignocellulolytic conditions, the SREBP pat

SUBMITTER: Qin L 

PROVIDER: S-EPMC5395666 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature