Ontology highlight
ABSTRACT:
SUBMITTER: Lan W
PROVIDER: S-EPMC5395726 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Lan Wanjun W Yamaguchi Satoshi S Yamamoto Teruyasu T Yamahira Shinya S Tan Modong M Murakami Naoka N Zhang Jingyan J Nakamura Motonao M Nagamune Teruyuki T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140602 9
G2A (from G2 accumulation) receptor is a member of the proton-sensing G-protein coupled receptor (GPCR) family and induces signal transduction events that regulate the cell cycle, proliferation, oncogenesis, and immunity. The mechanism by which G2A-mediated signal transduction is regulated by the extracellular pH remains unresolved. Here, we first visualize the pH-dependent G2A distribution change in living cells by a sortase A-mediated pulse labeling technology: the short-peptide tag-fused huma ...[more]