Sialylation regulates myofibroblast differentiation of human skin fibroblasts.

ABSTRACT:

Background

Fibroblasts are key players in maintaining skin homeostasis and in orchestrating physiological tissue repair and skin regeneration. Dysfunctions in fibroblasts that occur with aging and the senescent process lead to the delayed healing observed in elderly people. The molecular mechanisms leading to fibroblast dysfunction during aging and the senescent process have not yet been clarified. Previously, changes in patterns of glycosylation were observed in fibroblasts in aging and the senescent process, but the effect of these changes on the function of fibroblasts has not been well documented. Here, we investigated whether changes in glycosylation during the process to senescence may have functional effects on fibroblasts.

Methods

The changes in cell surface glycans

SUBMITTER: Sasaki N 

PROVIDER: S-EPMC5395757 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature