Systematic review with network meta-analysis: dual therapy for high-risk bleeding peptic ulcers.

ABSTRACT:

Background

Adding a second endoscopic therapy to epinephrine injection might improve hemostatic efficacy in patients with high-risk bleeding ulcers but the optimum modality remains unknown. We aimed to estimate the comparative efficacy of different dual endoscopic therapies for the management of bleeding peptic ulcers through random-effects Bayesian network meta-analysis.

Methods

Different databases were searched for controlled trials comparing dual therapy versus epinephrine monotherapy or epinephrine combined with another second modality until September, 30 2016. We estimated the ORs for rebleeding, surgery and mortality among different treatments. Adverse events were also evaluated.

Results

Seventeen eligible articles were included in the network meta-analysis. The

SUBMITTER: Shi K 

PROVIDER: S-EPMC5395769 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature