Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans.

ABSTRACT:

Background

Environmental stress can affect the viability or fecundity of an organism. Environmental stressors may affect the genome or the proteome and can cause cellular distress by contributing to protein damage or misfolding. This study examines the cellular response to environmental stress in the germline of the nematode, C. elegans.

Results

Salt stress, oxidative stress, and starvation, but not heat shock, induce the relocalization of ubiquitin, proteasome, and the TIAR-2 protein into distinct subnuclear regions referred to as stress induced nuclear granules (SINGs). The SINGs form within 1 h of stress initiation and do not require intertissue signaling. K48-linked polyubiquitin chains but not K63 chains are enriched in SINGs. Worms with a mutation in the conjugating en

SUBMITTER: Sampuda KM 

PROVIDER: S-EPMC5395811 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature