Integrated genomic analysis of mitochondrial RNA processing in human cancers.

ABSTRACT:

Background

The mitochondrial genome is transcribed as continuous polycistrons of RNA containing multiple genes. As a consequence, post-transcriptional events are critical for the regulation of gene expression and therefore all aspects of mitochondrial function. One particularly important process is the m¹A/m¹G RNA methylation of the ninth position of different mitochondrial tRNAs, which allows efficient processing of mitochondrial mRNAs and protein translation, and de-regulation of genes involved in these processes has been associated with altered mitochondrial function. Although mitochondria play a key role in cancer, the status of mitochondrial RNA processing in tumorigenesis is unknown.

Methods

We measure and assess mitochondrial RNA processing using

SUBMITTER: Idaghdour Y 

PROVIDER: S-EPMC5395977 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature