Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma.

ABSTRACT:

Background

Hypoxia imaging is a promising tool for targeted therapy but the links between imaging features and underlying molecular characteristics of the tumour have not been investigated. The aim of this study was to compare hypoxia biomarkers and gene expression in oropharyngeal squamous cell carcinoma (OPSCC) diagnostic biopsies with hypoxia imaged with ⁶⁴Cu-ATSM PET/CT.

Methods

⁶⁴Cu-ATSM imaging, molecular and clinical data were obtained for 15 patients. Primary tumour SUV_max, tumour to muscle ratio (TMR) and hypoxic volume were tested for association with reported hypoxia gene signatures in diagnostic biopsies. A putative gene signature for hypoxia in OPSCCs (hypoxic volume-associated gene signature (HVS)) was derived.

Results

Hy

SUBMITTER: Suh YE 

PROVIDER: S-EPMC5396120 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature