Default Mode Network Subsystems are Differentially Disrupted in Posttraumatic Stress Disorder.

ABSTRACT:

Background

Posttraumatic stress disorder (PTSD) is a psychiatric disorder characterized by debilitating re-experiencing, avoidance, and hyperarousal symptoms following trauma exposure. Recent evidence suggests that individuals with PTSD show disrupted functional connectivity in the default mode network, an intrinsic network that consists of a midline core, a medial temporal lobe (MTL) subsystem, and a dorsomedial prefrontal cortex (dMPFC) subsystem. The present study examined whether functional connectivity in these subsystems is differentially disrupted in PTSD.

Methods

Sixty-nine returning war Veterans with PTSD and 44 trauma-exposed Veterans without PTSD underwent resting state functional MRI (rs-fMRI). To examine functional connectivity, seeds were placed in the core hub

SUBMITTER: Miller DR 

PROVIDER: S-EPMC5396184 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature