Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols.

ABSTRACT: In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o-benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o-Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio-carboxylation of resveratrol on a preparative scale with 95% yield.

SUBMITTER: Plasch K 

PROVIDER: S-EPMC5396361 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature