ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse.

ABSTRACT:

Objective

Disulfiram is a potential cocaine addiction pharmacotherapy. Since dopamine deficiency has been found with cocaine addiction, our objective was to examine whether functional variants in the ankyrin repeat and kinase domain-containing 1 (ANKK1) and/or the dopamine receptor D2 (DRD2) genes interact with response to treatment with disulfiram.

Materials and methods

Cocaine and opioid codependent (DSM-IV) patients were stabilized on methadone and subsequently randomized into treatment groups - disulfiram (250 mg/day, N=31) or placebo (N=37). They were genotyped for ANKK1 (rs1800497) and DRD2 (rs2283265) polymorphisms, and the data were evaluated for an association between a cocaine-free state, as assessed by cocaine-free urine samples, and disulfiram treatment. Data wer

SUBMITTER: Spellicy CJ 

PROVIDER: S-EPMC5396392 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature