Associations between long-term exposure to PM_2.5 component species and blood DNA methylation age in the elderly: The VA normative aging study.

ABSTRACT:

Background

Long-term PM_2.5 exposure and aging have been implicated in multiple shared diseases; studying their relationship is a promising strategy to further understand the adverse impact of PM_2.5 on human health.

Objective

We assessed the relationship of major PM_2.5 component species (ammonium, elemental carbon, organic carbon, nitrate, and sulfate) with Horvath and Hannum DNA methylation (DNAm) age, two DNA methylation-based predictors of chronological age.

Methods

This analysis included 552 participants from the Normative Aging Study with multiple visits between 2000 and 2011 (n=940 visits). We estimated 1-year PM_2.5 species levels at participants' addresses using the GEOS-chem transport model. Blood DNAm-age was calcula

SUBMITTER: Nwanaji-Enwerem JC 

PROVIDER: S-EPMC5396466 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature