Intracellular Fibroblast Growth Factor 14: Emerging Risk Factor for Brain Disorders.

ABSTRACT: The finely tuned regulation of neuronal firing relies on the integrity of ion channel macromolecular complexes. Minimal disturbances of these tightly regulated networks can lead to persistent maladaptive plasticity of brain circuitry. The intracellular fibroblast growth factor 14 (FGF14) belongs to the nexus of proteins interacting with voltage-gated Na+ (Na_v) channels at the axonal initial segment. Through isoform-specific interactions with the intracellular C-terminal tail of neuronal Na_v channels (Na_v1.1, Na_v1.2, Na_v1.6), FGF14 controls channel gating, axonal targeting and phosphorylation in neurons effecting excitability. FGF14 has been also involved in synaptic transmission, plasticity and neurogenesis in the cortico-mesolimbic ci

SUBMITTER: Di Re J 

PROVIDER: S-EPMC5396478 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature