RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology.

ABSTRACT: We present a comprehensive software program, RAD-ADAPT, for the quantitative analysis of clonogenic assays in radiation biology. Two commonly used models for clonogenic assay analysis, the linear-quadratic model and single-hit multi-target model, are included in the software. RAD-ADAPT uses maximum likelihood estimation method to obtain parameter estimates with the assumption that cell colony count data follow a Poisson distribution. The program has an intuitive interface, generates model prediction plots, tabulates model parameter estimates, and allows automatic statistical comparison of parameters between different groups. The RAD-ADAPT interface is written using the statistical software R and the underlying computations are accomplished by the ADAPT software system for pharmacokinetic/p

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5396547 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature