Metabolic syndrome, serum uric acid and renal risk in patients with T2D.

ABSTRACT:

Background and aims

Metabolic Syndrome (Mets) and increased serum uric acid (SUA), are well known renal risk predictors and often coexist in patients with type 2 diabetes (T2D). Whether they independently contribute to the onset of CKD is at present unclear.

Methods and results

Within the AMD Annals database we identified patients with T2D and normal renal function and urine albumin excretion at baseline and regular follow-up visits during a 4-year period. Blood pressure, BMI, HDL, triglycerides, and SUA were available in 14,267 patients. The association between Mets and/or hyperuricemia (HU, top fifth gender specific quintile) and the occurrence of renal outcomes were evaluated.

Results

At baseline 59% of patients (n = 8,408) showed Mets and 18% (n = 2,584) HU. Over

SUBMITTER: Viazzi F 

PROVIDER: S-EPMC5396926 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature