CYP2C19 polymorphism frequency in Russian patients in Central Russia and Siberia with acute coronary syndrome.

ABSTRACT:

Purpose

The aim of this study is to investigate the frequency of CYP2C19*2, *3 allelic variants, associated with poor response to clopidogrel, and CYP2C19*17, associated with excessive response to clopidogrel, in patients with acute coronary syndrome (ACS) from Siberia and Moscow regions of Russia.

Patients and methods

The study included 512 ACS patients who were subsequently treated with coronary arterial stenting. The subjects assigned were from the cities of Central (Novosibirsk, Kemerovo), Eastern (Irkutsk), Northern (Surgut) Siberia regions and from Moscow region. The mean age of patients enrolled was 63.9±10.9 years. Among the assigned subjects, the proportion of men accounted for 80% and women 20%.

Results

According to the results obtained in the

SUBMITTER: Mirzaev KB 

PROVIDER: S-EPMC5397026 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature