Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum.

ABSTRACT: Multiple mechanisms such as genetic and epigenetic variations within a key gene may play a role in malarial susceptibility and response to anti-malarial drugs in the population. ABCB1 is one of the well-studied membrane transporter genes that code for the P-glycoprotein (an efflux protein) and whose effect on malaria disease predisposition and susceptibility to drugs remains to be understood. We studied the association of single nucleotide variations in human ABCB1 that influences its function in subjects with uncomplicated and complicated malaria caused by Plasmodium falciparum (Pf). Global DNA methylation and ABCB1 DNA promoter methylation levels were performed along with transcriptional response and protein expression in subjects with malaria and healthy controls. The rs2032582 locus wa

SUBMITTER: Gupta H 

PROVIDER: S-EPMC5397027 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature