Inducible super-enhancers are organized based on canonical signal-specific transcription factor binding elements.

ABSTRACT: Super-enhancers are established through the interactions of several enhancers and a large number of proteins, including transcription factors and co-regulators; however, the formation of these interactions is poorly understood. By re-analysing previously published estrogen receptor alpha (ERα) ChIP-seq data sets derived from the MCF-7 cell line, we observed that in the absence of stimulation, future super-enhancers are represented by one or a few transcription factor binding event(s) and these extraordinary enhancers possess a response element largely specific to the ERα dimer. Upon hormonal stimulation, these primary binding sites are surrounded by a large amount of ERα and the critical components of active enhancers, such as P300 and MED1, and together with neighbouring sites bound by ne

SUBMITTER: Bojcsuk D 

PROVIDER: S-EPMC5397169 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature