The histone demethylase PHF8 is a molecular safeguard of the IFNγ response.

ABSTRACT: A precise immune response is essential for cellular homeostasis and animal survival. The paramount importance of its control is reflected by the fact that its non-specific activation leads to inflammatory events that ultimately contribute to the appearance of many chronic diseases. However, the molecular mechanisms preventing non-specific activation and allowing a quick response upon signal activation are not yet fully understood. In this paper we uncover a new function of PHF8 blocking signal independent activation of immune gene promoters. Affinity purifications coupled with mass spectrometry analysis identified SIN3A and HDAC1 corepressors as new PHF8 interacting partners. Further molecular analysis demonstrated that prior to interferon gamma (IFNγ) stimulation, PHF8 is bound to a subse

SUBMITTER: Asensio-Juan E 

PROVIDER: S-EPMC5397186 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature