Association between neural reactivity and startle reactivity to uncertain threat in two independent samples.

ABSTRACT: Prior studies indicate that anxiety disorders are associated with heightened sensitivity to uncertain threat (U threat). Individual differences in reactivity to U threat have been measured in the laboratory with two methodologies-startle eyeblink potentiation and fMRI. While startle and fMRI are purported to relate to each other, very little research exists on whether individual differences in one measure are associated with individual differences in another and, thus, whether startle and fMRI capture shared mechanisms. Therefore, the current study was designed to investigate if and where in the brain measures of startle potentiation and fMRI BOLD signal correlate during response to U threat across two independent samples. Participants in both studies completed two threat anticipation task

SUBMITTER: Gorka SM 

PROVIDER: S-EPMC5397319 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature