Utilizing the planarian voltage-gated ion channel transcriptome to resolve a role for a Ca²⁺ channel in neuromuscular function and regeneration.

ABSTRACT: The robust regenerative capacity of planarian flatworms depends on the orchestration of signaling events from early wounding responses through the stem cell enacted differentiative outcomes that restore appropriate tissue types. Acute signaling events in excitable cells play an important role in determining regenerative polarity, rationalized by the discovery that sub-epidermal muscle cells express critical patterning genes known to control regenerative outcomes. These data imply a dual conductive (neuromuscular signaling) and instructive (anterior-posterior patterning) role for Ca²⁺ signaling in planarian regeneration. Here, to facilitate study of acute signaling events in the excitable cell niche, we provide a de novo transcriptome assembly from the planarian Dugesia japonica

SUBMITTER: Chan JD 

PROVIDER: S-EPMC5397384 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature