Knockdown of pp32 Increases Histone Acetylation and Ameliorates Cognitive Deficits.

ABSTRACT: Aging is a cause of cognitive decline in the elderly and the major risk factor for Alzheimer's disease, however, aging people are not all destined to develop into cognitive deficits, the molecular mechanisms underlying this difference in cognition of aging people are obscure. Epigenetic modifications, particularly histone acetylation in the nervous system, play a critical role in regulation of gene expression for learning and memory. An inhibitor of acetyltransferases (INHAT) is reported to suppress histone acetylation via a histone-masking mechanism, and pp32 is a key component of INHAT complex. In the present study, we divided ~18 m-old aged mice into the cognitive-normal and the cognitive-impaired group by Morris water maze, and found that pp32 level was significantly increased in the h

SUBMITTER: Feng Q 

PROVIDER: S-EPMC5397422 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature