Metabolic Profiles in Cell Lines Infected with Classical Swine Fever Virus.

ABSTRACT: Viruses require energy and biosynthetic precursors from host cells for replication. An understanding of the metabolic interplay between classical swine fever virus (CSFV) and host cells is important for exploring the complex pathological mechanisms of classical swine fever (CSF). In the current study, and for the first time, we utilized an approach involving gas chromatography coupled with mass spectrometry (GC-MS) to examine the metabolic profiles within PK-15 and 3D4/2 cells infected with CSFV. The differential metabolites of PK-15 cells caused by CSFV infection mainly included the decreased levels of glucose 6-phosphate [fold change (FC) = -1.94)] and glyceraldehyde-3-phosphate (FC = -1.83) during glycolysis, ribulose 5-phosphate (FC = -1.51) in the pentose phosphate pathway, guanosine

SUBMITTER: Gou H 

PROVIDER: S-EPMC5397473 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature