Neuro-degeneration profile of Alzheimer's patients: A brain morphometry study.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a primary and progressive neurodegenerative disorder, which is marked by cognitive deterioration and memory impairment. Atrophy of hippocampus and other basal brain regions is one of the most predominant structural imaging findings related to AD. Most studies have evaluated the pre-clinical and initial stages of AD through clinical trials using Magnetic Resonance Imaging. Structural biomarkers for advanced AD stages have not been evaluated yet, being considered only hypothetically.

Objective

To evaluate the brain morphometry of AD patients at all disease stages, identifying the structural neuro-degeneration profile associated with AD severity.

Material and methods

AD patients aged 60 years or over at different AD stages were re

SUBMITTER: Ramos Bernardes da Silva Filho S 

PROVIDER: S-EPMC5397580 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature